Kulczycki Jerzy, Łojkowska Wanda
I Kliniki Neurologicznej Instytutu Psychiatrii i Neurologii w Warszawie.
Neurol Neurochir Pol. 2003;37 Suppl 2:7-14.
Clinical diagnosis of sporadic CJD is usually confirmed by a typical EEG pattern and an increased level of protein 14-3-3 in the CSF, with specificity of 74% and 84%, respectively. However, both these tests are often negative in vCJD patients. Recently MR imaging has substantially improved the diagnosis of sCJD and vCJD. In sCJD patients hyperintense signal in T2-weighted sequences was found to be present in the neostriatum (the caudate nucleus and putamen) with specificity of 93%, while in vCJD cases signal hyperintensity was found in pulvinar thalami. The "pulvinar sign" was evidenced to be highly sensitive (79%) and specific (100%) for the diagnosis of the latter form of CJD.
散发性克雅氏病（sCJD）的临床诊断通常通过典型的脑电图模式和脑脊液中14-3-3蛋白水平升高来确诊，其特异性分别为74%和84%。然而，这两项检测在变异型克雅氏病（vCJD）患者中往往呈阴性。最近，磁共振成像（MR）显著改善了sCJD和vCJD的诊断。在sCJD患者中，T2加权序列上的高信号出现在新纹状体（尾状核和壳核），特异性为93%，而在vCJD病例中，丘脑枕出现信号高增强。“丘脑枕征”被证明对后一种形式的克雅氏病诊断具有高度敏感性（79%）和特异性（100%）。
