Friedlander Arthur H, Yagiela John A, Paterno Victoria I, Mahler Michael E
VA Greater Los Angeles Healthcare System, and Hospital Dental Service, UCLA Medical Center, CA 90073, USA.
J Calif Dent Assoc. 2003 Sep;31(9):693-702.
Fragile X, Rett, and Prader-Willi syndromes are a group of inherited disorders that often present with varying degrees of mental retardation and challenging behaviors. Dentists caring for individuals with these disorders must be familiar with the manifestations of these diseases and their associated features so they can garner the maximum level of cooperation from the patient. They must also be familiar with the medications (anticonvulsants, antihypertensives, antidepressants, antipsychotics, and central nervous system stimulants) used to treat the associated behaviors, because many of these pharmaceuticals cause clinically evident orofacial and systemic reactions, and may precipitate adverse interactions with dental therapeutic agents.
脆性X综合征、雷特综合征和普拉德-威利综合征是一组遗传性疾病，常伴有不同程度的智力迟钝和具有挑战性的行为。为患有这些疾病的个体提供护理的牙医必须熟悉这些疾病的表现及其相关特征，以便能从患者那里获得最大程度的配合。他们还必须熟悉用于治疗相关行为的药物（抗惊厥药、抗高血压药、抗抑郁药、抗精神病药和中枢神经系统兴奋剂），因为这些药物中有许多会引起临床上明显的口腔颌面部和全身反应，并且可能与牙科治疗剂产生不良相互作用。
