Shim Sang Hee, Kim Ju Sun, Kang Sam Sik, Son Kun Ho, Bae KiHwan
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Arch Pharm Res. 2003 Sep;26(9):709-15. doi: 10.1007/BF02976678.
Aconitum jaluense Komar. (Ranunculaceae) is one of the Aconitum plants growing in Korean peninsula. An investigation of the alkaloidal constituents of this species led to the isolation of seven C19-norditerpenoid and a C20-diterpenoid alkaloid. Three of them have been identified as neoline, mesaconitine, and hypaconitine, which were isolated from this plant collected from Mt. Bultasan in the north part. The other five alkaloids were determined as lipomesaconitine, lipohypaconitine, 15alpha-hydroxyneoline, hokbusine A, and napelline, which have not been found in this plant. Structures of those alkaloids were determined on the basis of their spectral data. It is of interest to note that a comparison of the present work and the previous report showed some differences in the alkaloidal contents.
朝鲜乌头(毛茛科)是生长在朝鲜半岛的乌头属植物之一。对该物种生物碱成分的研究导致分离出七种C19-去甲二萜类和一种C20-二萜类生物碱。其中三种已被鉴定为新乌宁碱、中乌头碱和次乌头碱,它们是从北部布尔塔山采集的这种植物中分离出来的。另外五种生物碱被确定为脂中乌头碱、脂次乌头碱、15α-羟基新乌宁碱、霍布辛A和那碎因,在这种植物中尚未发现。这些生物碱的结构是根据它们的光谱数据确定的。值得注意的是,将本研究与先前的报告进行比较,发现生物碱含量存在一些差异。