Kim D H, Sabatini D M
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Curr Top Microbiol Immunol. 2004;279:259-70. doi: 10.1007/978-3-642-18930-2_15.
mTOR/RAFT1/FRAP is the target of the FKBP12-rapamycin complex as well as a central component of a nutrient- and hormone-sensitive pathway that controls cellular growth. Recent work reveals that mTOR interacts with a novel evolutionarily conserved protein that we named raptor, for "regulatory associated protein of mTOR." Raptor has several roles in the mTOR pathway. It is necessary for nutrient-mediated activation of the downstream effector S6K1 and increases in cell size. In addition, under conditions that repress the mTOR pathway, the association of raptor with mTOR is strengthened, leading to a decrease in mTOR kinase activity. Raptor is a critical component of the mTOR pathway that regulates cell growth in response to nutrient levels by associating with mTOR.
mTOR/RAFT1/FRAP是FKBP12-雷帕霉素复合物的作用靶点，也是控制细胞生长的营养和激素敏感途径的核心组成部分。最近的研究表明，mTOR与一种新的进化保守蛋白相互作用，我们将其命名为raptor，即“mTOR的调节相关蛋白”。Raptor在mTOR途径中具有多种作用。它对于营养物质介导的下游效应器S6K1的激活以及细胞大小的增加是必需的。此外，在抑制mTOR途径的条件下，raptor与mTOR的结合会增强，导致mTOR激酶活性降低。Raptor是mTOR途径的关键组成部分，通过与mTOR结合来调节细胞生长以响应营养水平。
