氢离子动力学与癌症血管生成及抗血管生成中的钠氢交换体
Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis.
作者信息
Orive G, Reshkin S J, Harguindey S, Pedraz J L
机构信息
Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology, University of the Basque Country, C Paseo de la Universidad no. 7, 01006 Vitoria, Spain.
出版信息
Br J Cancer. 2003 Oct 20;89(8):1395-9. doi: 10.1038/sj.bjc.6601286.
Abstract
Tumour angiogenesis and cellular pH regulation, mainly represented by Na(+)/H(+) antiporter exchange, have been heretofore considered unrelated subfields of cancer research. In this short review, the available experimental evidence relating these areas of modern cancer research is introduced. This perspective also helps to design a new approach that facilitates the opening and development of novel research lines oriented towards a rational incorporation of anticancer drugs into more selective and less toxic therapeutic protocols. The final aim of these efforts is to control cancer progression and dissemination through the control of tumour angiogenesis. Finally, different antiangiogenic drugs that can already be clinically used to this effect are briefly presented.
摘要
肿瘤血管生成和细胞pH调节，主要由Na(+)/H(+)反向转运体交换代表，迄今为止一直被认为是癌症研究中不相关的子领域。在这篇简短的综述中，介绍了将现代癌症研究的这些领域联系起来的现有实验证据。这种观点也有助于设计一种新方法，促进新研究方向的开启和发展，这些研究方向旨在将抗癌药物合理地纳入更具选择性和毒性更小的治疗方案中。这些努力的最终目标是通过控制肿瘤血管生成来控制癌症的进展和扩散。最后，简要介绍了目前临床上已可用于此目的的不同抗血管生成药物。
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