抗氧化治疗对少精子症和弱精子症男性的影响。

Effects of antioxidant treatment in oligozoospermic and asthenozoospermic men.

作者信息

Suzuki Mina, Kurabayashi Takumi, Yamamoto Yasuaki, Fujita Kazuyuki, Tanaka Kenichi

机构信息

Department of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Japan.

出版信息

J Reprod Med. 2003 Sep;48(9):707-12.

PMID:14562636

Abstract

OBJECTIVE

To evaluate the effect of sairei-to, an herbal medicine, as an antioxidant in oligozoospermia and asthenozoospermia (nonnormozoospermia).

STUDY DESIGN

Forty-seven nonnormozoospermic and 16 normozoospermic men were the subjects of this prospective clinical study. After sairei-to (9.0 g/d) was administered daily to the 2 groups for 3 months, sperm parameters, serum hormones and superoxide dismutase (SOD) activity in the serum and the seminal plasma was analyzed. The testicular artery was also assessed.

RESULTS

After therapy, serum hormones and SOD activity did not change significantly in either group. Although men with normozoospermia did not undergo a significant change in sperm conditions or testicular artery flow, total sperm concentration (17.1 +/- 20.0 versus 28.7 +/- 35.5 x 10(6)/mL, P = .02) and sperm motility (30.1% +/- 21.6 versus 45.8% +/- 24.4, P < .0001) were significantly increased, and the pulsatility index of the testicular artery (2.03 +/- 0.84 versus 1.64 +/- 0.48, P = .04) was significantly decreased in nonnormozoospermia.

CONCLUSION

Treatment with the herbal antioxidant sairei-to improves sperm condition and testicular artery flow in nonnormozoospermia.

摘要

目的

评估汉方制剂柴苓汤作为抗氧化剂对少精子症和弱精子症（非正常精子症）的作用。

研究设计

本前瞻性临床研究以47例非正常精子症男性和16例正常精子症男性为研究对象。两组均每日服用柴苓汤（9.0克/天），持续3个月，之后分析精子参数、血清激素以及血清和精浆中的超氧化物歧化酶（SOD）活性。同时对睾丸动脉进行评估。

结果

治疗后，两组的血清激素和SOD活性均无显著变化。虽然正常精子症男性的精子状况和睾丸动脉血流未发生显著改变，但在非正常精子症患者中，精子总浓度（17.1±20.0对28.7±35.5×10⁶/mL，P = 0.02）和精子活力（30.1%±21.6对45.8%±24.4，P < 0.0001）显著增加，睾丸动脉搏动指数（2.03±0.84对1.64±0.48，P = 0.04）显著降低。