吸烟对不育男性抗氧化剂水平及白细胞精子症存在情况的影响：一项前瞻性研究。

Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study.

作者信息

Pasqualotto Fábio Firmbach, Umezu Fernanda Medeiros, Salvador Mirian, Borges Edson, Sobreiro Bernardo Passos, Pasqualotto Eleonora Bedin

机构信息

Instituto de Biotecnologia, Universidade de Caxias do Sul, Caxias do Sul, Brazil.

出版信息

Fertil Steril. 2008 Aug;90(2):278-83. doi: 10.1016/j.fertnstert.2008.02.123. Epub 2008 May 7.

DOI:10.1016/j.fertnstert.2008.02.123

PMID:18462724

Abstract

OBJECTIVE

To evaluate the effect of cigarette smoking on antioxidant levels and the presence of leukocytospermia in infertile men.

DESIGN

Prospective study.

SETTING

Academic medical center.

PATIENT(S): Ten fertile donors and 112 infertile patients were included in the study.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Semen analysis was performed according to the World Health Organization guideline. The activity of the superoxide dismutase was based on the adrenochrome concentration, and the catalase activity was determined by the velocity of hydrogen peroxide consumption.

RESULT(S): Lower levels of superoxide dismutase and catalase were seen in infertile patients compared with fertile donors. Superoxide dismutase was significantly correlated with sperm concentration and negatively correlated with leukocytospermia. In addition, leukocytospermia was inversely correlated with sperm motility. Superoxide dismutase levels were negatively related to cigarette smoking.

CONCLUSION(S): Cigarette smoking may impair sperm motility and decrease the antioxidant activity (negative correlation with superoxide dismutase) in the seminal plasma.

摘要