Tomlinson C W, Dhalla N S
Recent Adv Stud Cardiac Struct Metab. 1976;12:191-8.
Left ventricular hypertrophy was seen in catheterized, uninfected rabbits, whereas contractile failure superimposed upon hypertrophy was observed in catheterized animals after injection with Streptococcus viridans within six days. The infected animals showed marked changes in the ultrastructure of the left heart in comparison to the uninfected rabbits. The levels of calcium and potassium were decreased, whereas sodium was increased in both infected and uninfected hearts; however, magnesium levels did not change in uninfected hearts but were decreased at three days and increased at six days of infection. The microsomal calcium uptake was decreased in six-day uninfected as well as three-and six-day infected hearts. On the other hand, the mitochondrial calcium uptake was increased in six-day uninfected and three-day infected hearts but decreased in six-day infected hearts. The sarcolemmal calcium binding and (Na+,K+)ATPase activities were decreased in six-day uninfected as well as three- and six-day infected hearts. These results dramatic changes in intracellular calcium metabolism in myocardial hypertrophy and failure caused by bacterial infection.
在插管未感染的兔子中观察到左心室肥厚，而在插管后六天内注射绿色链球菌的动物中，肥厚的心脏出现了收缩功能衰竭。与未感染的兔子相比，感染动物的左心超微结构有明显变化。感染和未感染的心脏中钙和钾水平均降低，而钠水平升高；然而，未感染心脏中的镁水平没有变化，但在感染三天时降低，感染六天时升高。在未感染六天以及感染三天和六天的心脏中，微粒体钙摄取减少。另一方面，线粒体钙摄取在未感染六天和感染三天的心脏中增加，但在感染六天的心脏中减少。在未感染六天以及感染三天和六天的心脏中，肌膜钙结合和（钠 +，钾 +）ATP 酶活性降低。这些结果表明细菌感染导致心肌肥厚和衰竭时细胞内钙代谢发生了显著变化。
