Tomlinson C W, Dhalla N S
Lab Invest. 1975 Sep;33(3):316-23.
Infective endocarditis was induced in 15 catheterized rabbits by a single intravenous injection of Streptococcus viridans and the papillary muscles from the left ventricle were examined for histologic and ultrastructural changes at 3 and 6 days of infection. Papillary muscles from 10 normal and 12 catheterized uninfected animals were used for comparison. Catheterized animals, infected and uninfected, had cardiac hypertrophy and papillary muscles which showed an increase in myofiber size and some interstitial edema. The muscle from infected hearts had areas of focal necrosis, diffuse monocytic infiltration, and loss of normal myocardial architecture. The papillary muscles from catheterized uninfected animals showed some degree of mitochondrial and sarcotubular swelling as well as contracture of myofibrils; the infected myocardium exhibited dramatic changes in ultrastructure such as mitochondrial swelling and destruction, sarcotubular swelling, separation of the intercalated disc, and myofibrillar contracture and disruption. These histopathologic and ultrastructural changes in papillary muscles from rabbits with bacterial endocarditis are indicative of the presence of myocardial cell damage.
通过单次静脉注射绿色链球菌，在15只插有导管的兔子中诱发感染性心内膜炎，并在感染的第3天和第6天检查左心室乳头肌的组织学和超微结构变化。使用来自10只正常和12只插有导管的未感染动物的乳头肌作为对照。插有导管的感染和未感染动物均出现心脏肥大，乳头肌肌纤维大小增加且有一些间质水肿。感染心脏的肌肉有局灶性坏死区域、弥漫性单核细胞浸润以及正常心肌结构丧失。插有导管的未感染动物的乳头肌表现出一定程度的线粒体和肌小管肿胀以及肌原纤维挛缩；感染的心肌在超微结构上表现出显著变化，如线粒体肿胀和破坏、肌小管肿胀、闰盘分离以及肌原纤维挛缩和断裂。细菌性心内膜炎兔子乳头肌的这些组织病理学和超微结构变化表明存在心肌细胞损伤。
