New approaches to invasive fungal infections.

Invasive fungal infections are typically difficult to prevent, diagnose, and treat; consequently, fungal infection-related mortality has become high, particularly among patients with prolonged neutropenia and severe graft-versus-host disease. However, much recent progress has been made in understanding the immune response to fungi and the epidemiology of infection, and new diagnostic tests and antifungal drugs have become available. This review will describe these most recent developments with the goal of evaluating new approaches to prevent, diagnose, and treat invasive fungal infections.