Bow Eric J
Sections of Infectious Diseases and Haematology/Oncology, Department of Internal Medicine, The University of Manitoba, Manitoba, Winnipeg, Manitoba, Canada.
Br J Haematol. 2008 Jan;140(2):133-52. doi: 10.1111/j.1365-2141.2007.06906.x.
Invasive infections because of opportunistic yeasts and moulds have contributed significantly to the morbidity and mortality associated with potentially curative treatment for haematological malignancies. Many risk factors have been identified that permit the clinician to predict the likelihood of these infections. The diagnostic process involves maintaining a high index of suspicion based upon an understanding of the clinical circumstances under which invasive fungal infections occur, of the spectrum of fungal syndromes, and of the advantages and limitations of diagnostic testing strategies now available. Treatment strategies may be categorized as prophylactic, pre-emptive, empiric, or directed based upon the circumstances. The therapeutic options have increased in recent years but are not applicable to all clinical circumstances. These considerations are discussed.
由机会性酵母和霉菌引起的侵袭性感染，在血液系统恶性肿瘤的潜在治愈性治疗相关的发病率和死亡率中起了重要作用。已经确定了许多风险因素，使临床医生能够预测这些感染的可能性。诊断过程包括基于对侵袭性真菌感染发生的临床情况、真菌综合征谱以及现有诊断测试策略的优缺点的理解，保持高度的怀疑指数。治疗策略可根据情况分为预防性、先发制性、经验性或针对性的。近年来治疗选择有所增加，但并非适用于所有临床情况。本文将讨论这些注意事项。
