Udelson James E, Patten Richard D, Konstam Marvin A
Division of Cardiology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
Rev Cardiovasc Med. 2003;4 Suppl 3:S3-12.
An understanding of the process of left ventricular (LV) remodeling has led to greater knowledge of the pathophysiology of heart failure syndrome. This article examines the relationship between LV remodeling and clinical outcomes of heart failure syndrome from several different perspectives. The studies cited suggest that the post-myocardial infarction process is related to and associated with long-term progression of LV dysfunction, heart failure symptoms, and mortality. It is also demonstrated that drug therapies that slow or reverse the remodeling process appear to have favorable natural history effects in the short term as well as during long-term therapy.
对左心室（LV）重塑过程的理解使人们对心力衰竭综合征的病理生理学有了更深入的认识。本文从几个不同角度探讨了LV重塑与心力衰竭综合征临床结局之间的关系。引用的研究表明，心肌梗死后的过程与LV功能障碍、心力衰竭症状及死亡率的长期进展相关且存在关联。研究还表明，减缓或逆转重塑过程的药物疗法在短期以及长期治疗期间似乎都对自然病程有有利影响。
