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血栓弹力图:临床实践的现状与未来展望

Thrombelastography. Present and future perspectives in clinical practice.

作者信息

Di Benedetto P, Baciarello M, Cabetti L, Martucci M, Chiaschi A, Bertini L

机构信息

Department of Anesthesiology and Critical Care S. Andrea University Hospital, Rome, Italy.

出版信息

Minerva Anestesiol. 2003 Jun;69(6):501-9, 509-15.

PMID:14564249
Abstract

Thrombelastography (TEG) is a method for evaluating the viscoelastic properties of the blood clot, from its formation to its lysis. All major surgeries may be associated with massive blood loss, with blood component transfusion therapy often becoming mandatory. The clinician's goal is thus to optimize and possibly minimize blood components usage. To this end, TEG allows for a qualitative and dynamic analysis of the specific blood clotting process, from clot formation through its lysis, highlighting alterations at every single step in the cascade. With TEG is thus possible to know if bleeding is due to a failure to provide adequate surgical hemostasis, if there is platelet dysfunction, or to detect anomalies in coagulation proteases or their inhibitors, or if the blood loss is associated to early, excessive fibrinolysis. The theoretical advantages of TEG are the ease of performing the test, the fast sample reading times (now 30 minutes) and the informative

摘要

血栓弹力图(TEG)是一种评估血凝块从形成到溶解过程中粘弹性特性的方法。所有大型手术都可能伴有大量失血,血液成分输血治疗常常成为必要手段。因此,临床医生的目标是优化并尽可能减少血液成分的使用。为此,TEG能够对特定的凝血过程进行定性和动态分析,从凝块形成到溶解,突出级联反应中每一步的变化。通过TEG,可以了解出血是否是由于未能提供足够的手术止血、是否存在血小板功能障碍、是否能检测到凝血蛋白酶或其抑制剂的异常,或者失血是否与早期过度纤溶有关。TEG的理论优势在于检测操作简便、样本读取时间快(现在为30分钟)且信息丰富。

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