Feillet-Coudray Christine, Lafay Sophie, Tressol Jean Claude, Gueux Elyett, Mazur André, Coudray Charles
Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques & Micronutriments INRA, Theix, 63122, St Genès Champanelle, France.
Eur J Nutr. 2003 Oct;42(5):279-86. doi: 10.1007/s00394-003-0423-5.
Magnesium (Mg) intake is below the recommended daily allowances in many developed countries. Mg-rich mineral waters can provide significant amounts of energy-free Mg and thus help to meet Mg requirements. We assessed the effects of different Mg-rich mineral waters on overall intestinal Mg absorption and urinary Mg excretion in 40 rats split into four groups: one received distilled water, another a solution of MgCl(2) and the others two different mineral waters, sulphated water (Hépar) and carbonated water (Badoit) mixed with the diet and as drinking water, for four weeks. The rats were given 3 mg of (26)Mg orally and 0.5 mg of (25)Mg intravenously. They were placed in metabolic cages, and diet consumption, and faeces and urine excretion were monitored during the last four days of the experiment. The rats were then sacrificed and blood was sampled. Mg levels in the diet, faeces, urine and biological samples were measured by atomic absorption spectrometry. Mg stable isotope measurements were performed by ICP/MS. Mg-rich mineral waters significantly increased net intestinal absorption of Mg by more than 30%, but the proportions of both apparent and true intestinal absorption of Mg were similar in all four groups. Thus, net and fractional retention of Mg were similar in the three Mg-supplemented groups. In conclusion, both types of Mg-rich mineral waters studied similarly increased both absorption and urinary excretion of Mg with no positive effect on the overall retention of Mg, probably because the Mg status of the rats was already satisfactory.
在许多发达国家，镁（Mg）的摄入量低于推荐的每日摄入量。富含镁的矿泉水可以提供大量的无能量镁，从而有助于满足镁的需求。我们将40只大鼠分为四组，评估了不同富含镁的矿泉水对肠道整体镁吸收和尿镁排泄的影响：一组饮用蒸馏水，另一组饮用MgCl₂溶液，另外两组分别饮用与饮食混合并作为饮用水的两种不同矿泉水，即硫酸化水（Hépar）和碳酸水（Badoit），持续四周。给大鼠口服3mg的（²⁶）Mg，静脉注射0.5mg的（²⁵）Mg。将它们置于代谢笼中，在实验的最后四天监测饮食消耗、粪便和尿液排泄情况。然后处死大鼠并采集血液样本。通过原子吸收光谱法测量饮食、粪便、尿液和生物样本中的镁水平。通过电感耦合等离子体质谱法进行镁稳定同位素测量。富含镁的矿泉水使肠道镁的净吸收显著增加了30%以上，但在所有四组中，镁的表观和真实肠道吸收比例相似。因此，在三个补充镁的组中，镁的净保留和分数保留相似。总之，所研究的两种富含镁的矿泉水同样增加了镁的吸收和尿排泄，对镁的整体保留没有积极影响，可能是因为大鼠的镁状态已经令人满意。
