真菌锰过氧化物酶对亚当氏气剂（氯化二苯胺胂）的转化作用。

Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase.

作者信息

Haas R, Tsivunchyk O, Steinbach K, von Löw E, Scheibner K, Hofrichter M

机构信息

Office of Environmental Investigation and Research, Stadtwaldstrasse 45a, 35037 Marburg, Germany.

出版信息

Appl Microbiol Biotechnol. 2004 Feb;63(5):564-6. doi: 10.1007/s00253-003-1453-x. Epub 2003 Oct 16.

DOI:10.1007/s00253-003-1453-x

PMID:14564485

Abstract

Fungal manganese peroxidase was found to convert the persistent chemical warfare agent adamsite (phenarsarzin chloride) in a cell-free reaction mixture containing sodium malonate, Mn(2+) ions, and reduced glutathione. The organo-arsenical compound disappeared completely within 48 h accompanied by the formation of a more polar metabolite with a clearly modified UV spectrum. Thus, As(III) in the adamsite molecule was oxidized by manganese peroxidase to As(V) which added dioxygen and released chloride.

摘要

在含有丙二酸钠、锰离子（Mn(2+)）和还原型谷胱甘肽的无细胞反应混合物中，发现真菌锰过氧化物酶能转化持久性化学战剂亚当氏气（氯化二苯胺胂）。这种有机砷化合物在48小时内完全消失，同时形成了一种极性更强的代谢产物，其紫外光谱有明显改变。因此，亚当氏气分子中的砷（III）被锰过氧化物酶氧化为砷（V），后者添加了双氧并释放出氯离子。