Saijo Fumito, Naito Hiroo, Funayama Yuji, Fukushima Kouhei, Shibata Chikashi, Hashimoto Akihiko, Kitayama Taku, Nagao Munenori, Matsuno Seiki, Sasaki Iwao
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
J Gastroenterol. 2003;38(9):905-8. doi: 10.1007/s00535-002-1170-8.
The somatostatin analogue octreotide was effective in controlling systemic effects related to multiple liver metastases from a gastrinoma. A 61-year-old man underwent distal gastrectomy for gastrinoma in the duodenum, because a curative resection was not feasible due to metastases found in paraaortic lymph nodes during operation. Multiple liver metastases, associated with an increase in serum gastrin concentration, were found by magnetic resonance imaging 16 months after the operation. Although chemotherapy with dimethyltrizenoimidazole carboxamide was not effective, subcutaneous administration of octreotide was effective in controlling the growth of the liver metastases and in stabilizing serum gastrin. The patient now receives subcutaneous injections of octreotide, at 200 microg a day, twice a week, as an outpatient.
生长抑素类似物奥曲肽在控制胃泌素瘤所致多发性肝转移的全身效应方面有效。一名61岁男性因十二指肠胃泌素瘤接受了远端胃切除术，因为术中发现腹主动脉旁淋巴结转移，无法进行根治性切除。术后16个月通过磁共振成像发现多发性肝转移，伴有血清胃泌素浓度升高。尽管使用二甲基三氮烯咪唑甲酰胺化疗无效，但皮下注射奥曲肽在控制肝转移生长和稳定血清胃泌素方面有效。该患者现作为门诊病人，每周两次，每次皮下注射200微克奥曲肽。
