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一例伴有肝转移的散发性胃泌素瘤的临床表现、诊断及治疗

Presentation, Diagnosis, and Treatment of a Sporadic Gastrinoma With Liver Metastases.

作者信息

Jadhav Alisha, Ayyat Mumen, Serafini Francesco M

机构信息

Surgery, St. George's University School of Medicine, Brooklyn, USA.

Surgery, Brookdale University Hospital Medical Center, Brooklyn, USA.

出版信息

Cureus. 2024 May 31;16(5):e61426. doi: 10.7759/cureus.61426. eCollection 2024 May.

DOI:10.7759/cureus.61426
PMID:38947692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11214729/
Abstract

A gastrinoma is a rare and potentially deadly tumor. Gastrinomas can be difficult to detect at first, given that affected patients can present with nonspecific symptoms, such as anemia, weight loss, and diarrhea, leading to a large list of differentials. The symptoms can be hard to manage, and the treatment almost always includes surgical intervention. Gastrinomas often metastasize to the liver, in which case, the only curative treatment option is surgical resection of the primary tumor along with as many metastatic lesions as possible. This report reviews the case of a 59-year-old female who presented with symptoms of anemia and an upper gastrointestinal bleed, who was discovered to have a pancreatic gastrinoma with more than 12 liver metastases. It also describes the management of her critical condition, which was used to give her the best chance of survival.

摘要

胃泌素瘤是一种罕见且可能致命的肿瘤。由于受影响的患者可能出现贫血、体重减轻和腹泻等非特异性症状,胃泌素瘤起初可能难以检测,这导致了大量不同的鉴别诊断。这些症状可能难以控制,治疗几乎总是包括手术干预。胃泌素瘤常转移至肝脏,在这种情况下,唯一的治愈性治疗选择是手术切除原发性肿瘤以及尽可能多的转移病灶。本报告回顾了一名59岁女性的病例,该女性出现贫血和上消化道出血症状,被发现患有胰腺胃泌素瘤并伴有12个以上的肝转移灶。报告还描述了对其危急病情的处理,这为她提供了最佳的生存机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f32/11214729/a8d7df76550f/cureus-0016-00000061426-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f32/11214729/fece7a3a84c0/cureus-0016-00000061426-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f32/11214729/a8d7df76550f/cureus-0016-00000061426-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f32/11214729/fece7a3a84c0/cureus-0016-00000061426-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f32/11214729/a8d7df76550f/cureus-0016-00000061426-i02.jpg

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本文引用的文献

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Sporadic and MEN1-related gastrinoma and Zollinger-Ellison syndrome: differences in clinical characteristics and survival outcomes.散发性和 MEN1 相关性胃泌素瘤和卓-艾综合征:临床特征和生存结局的差异。
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Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.胃泌素瘤和卓-艾综合征:新旧疗法管理之间的路线图。
World J Gastroenterol. 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890.
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《Zollinger-Ellison 综合征的外科治疗:经典观点与当前争议》。
World J Gastroenterol. 2019 Aug 28;25(32):4673-4681. doi: 10.3748/wjg.v25.i32.4673.
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Resection of the primary tumor improves survival in patients with gastro-entero-pancreatic neuroendocrine neoplasms with liver metastases: A SEER-based analysis.基于 SEER 的分析:原发肿瘤切除术可改善伴肝转移的胃肠胰神经内分泌肿瘤患者的生存。
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