Stretton Serina, Jalbert Isabelle, Sweeney Deborah F
Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Cornea and Contact Lens Research Unit, School of Optometry, Sydney, Australia.
Ophthalmol Clin North Am. 2003 Sep;16(3):327-40, v. doi: 10.1016/s0896-1549(03)00053-1.
Contact lenses made from materials of low-oxygen permeability (Dk) do not meet the oxygen requirements of the cornea for overnight wear. Long-term extended wear of these lenses results in chronic changes to all layers of the cornea, many of which are associated with hypoxia. High-Dk silicone hydrogel and gas permeable lenses are now available for 30-night continuous wear. The high-oxygen transmissibilities of these lenses have enabled the development of a successful continuous wear modality by eliminating the hypoxic effects of long-term wear. Presently, the focus is on improving lens performance by developing lenses that are more biocompatible, provide greater comfort, and maintain a stable tear film without inflammatory or mechanically induced adverse events.
由低氧渗透率（Dk）材料制成的隐形眼镜无法满足角膜过夜佩戴的氧气需求。长期佩戴这些镜片会导致角膜各层出现慢性变化，其中许多变化与缺氧有关。现在有高Dk值的硅水凝胶和透气镜片可供连续佩戴30晚。这些镜片的高透氧性通过消除长期佩戴的缺氧影响，使得一种成功的连续佩戴方式得以发展。目前，重点在于通过开发更具生物相容性、提供更大舒适度并保持稳定泪膜且无炎症或机械性诱发不良事件的镜片来提高镜片性能。
