Riapis L A, Filatov N N, Salova N Ia
Sechenov Medical Academy, Center of State Sanitary and Epidemiological Surveillance, Moscow, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2003 Sep-Oct(5):49-54.
Data on molecular epidemiology of bacterial infections is summarized. The term definitions of "molecular epidemiology", "taxonomic species" are given, the limits and species structure of prokaryotes are described. The basic mechanisms of the prokaryotes variability in the epidemic process, as well as the possibilities and limitations of microbiological, molecular-biological and population--genetic typing methods, are characterized. The tactics of molecular-biological studies in analyzing the population structure on the global, regional and local levels is presented. The economic effectiveness of measures taken with due consideration of information on the clonal structure of causative agents of hospital infections is shown.
总结了细菌感染的分子流行病学数据。给出了“分子流行病学”“分类物种”的术语定义，描述了原核生物的界限和物种结构。阐述了原核生物在流行过程中的变异基本机制，以及微生物学、分子生物学和群体遗传学分型方法的可能性和局限性。介绍了在全球、区域和地方层面分析群体结构的分子生物学研究策略。展示了在充分考虑医院感染病原体克隆结构信息的情况下所采取措施的经济效益。
