连接核苷支架的新型固体载体。
New solid supports linking nucleoside scaffolds.
作者信息
de Champdoré Marcella, De Napoli Lorenzo, Di Fabio Giovanni, Messere Anna, Montesarchio Daniela, Piccialli Gennaro
机构信息
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Napoli, Italy.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):695-7. doi: 10.1081/NCN-120022612.
An easy and efficient strategy to obtain new nucleoside based solid supports in which the nucleoside moieties have been anchored to the solid support through the nucleobase is here proposed. A simple and efficient solid-phase synthesis of 5' and 3'-derivatized uridine analogues has so been developed, following methodologies well established in organic chemistry.
本文提出了一种简便有效的策略，用于获得新型核苷基固相载体，其中核苷部分通过核碱基连接到固相载体上。遵循有机化学中已确立的方法，现已开发出一种简单高效的5'和3'-衍生化尿苷类似物的固相合成方法。
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