4'-C-甲基-β-D-呋喃核糖基嘌呤和嘧啶核苷再探讨。
4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited.
作者信息
Griffon J F, Dukhan D, Pierra C, Benzaria S, Loi A G, La Colla P, Sommadossi J P, Gosselin G
机构信息
Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, France.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):707-9. doi: 10.1081/NCN-120022615.
PMID:14565259
Abstract
In order to evaluate their antiviral properties, a series of 4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides has been prepared. Unfortunately, none of these 4'-branched nucleosides showed any antiviral activity or cytotoxcity when tested against HIV, HBV, and Yellow Fever virus.
摘要
为了评估它们的抗病毒特性，已制备了一系列4'-C-甲基-β-D-呋喃核糖基嘌呤和嘧啶核苷。遗憾的是，当针对HIV、HBV和黄热病病毒进行测试时，这些4'-支链核苷均未显示出任何抗病毒活性或细胞毒性。
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