Broadstone R V, Gray P R, Robinson N E, Derksen F J
Pulmonary Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
Am J Vet Res. 1992 Oct;53(10):1813-7.
The effect of IV administration of the alpha 2-adrenoceptor agonist xylazine hydrochloride (0.5 mg/kg of body weight) was examined in ponies with recurrent obstructive pulmonary disease, commonly called heaves. Six ponies with the disease (principals) were studied during clinical remission and during an acute attack of airway obstruction precipitated by stabling and feeding of dusty hay. Six control ponies were also studied. In principal ponies with airway obstruction, xylazine administration significantly (P < 0.05) decreased pulmonary resistance and increased dynamic compliance, but did not affect PaO2 or PaCO2. The alpha 2-antagonist yohimbine blocked the pulmonary effects of xylazine. Administration of saline solution was without effect in both groups of ponies at all periods and xylazine did not have effect in controls or in principals in clinical remission.
在患有复发性阻塞性肺部疾病（通常称为气喘）的小马中，研究了静脉注射α2 -肾上腺素能受体激动剂盐酸赛拉嗪（0.5毫克/千克体重）的效果。在临床缓解期以及因圈养和喂食多尘干草引发气道阻塞急性发作期间，对六匹患有该疾病的小马（主要研究对象）进行了研究。还对六匹对照小马进行了研究。在患有气道阻塞的主要研究对象小马中，注射赛拉嗪显著（P < 0.05）降低了肺阻力并增加了动态顺应性，但对动脉血氧分压（PaO2）或动脉血二氧化碳分压（PaCO2）没有影响。α2 -拮抗剂育亨宾阻断了赛拉嗪的肺部效应。在所有时间段，两组小马注射生理盐水均无效果，并且赛拉嗪对临床缓解期的对照小马或主要研究对象小马均无作用。
