含己糖醇部分的利巴韦林类似物的合成及抗病毒活性评价
Synthesis and antiviral evaluation of ribavirin congeners containing a hexitol moiety.
作者信息
Van Aerschot A, Schepers G, Busson R, Neyts J, De Clercq E, Herdewijn P
机构信息
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):849-51. doi: 10.1081/NCN-120022669.
PMID:14565294
Abstract
Several ribavirin congeners containing a hexitol moiety were prepared via ring opening of two different epoxides with the methylcarboxylate ester of triazole and further elaboration. Unfortunately, none of the newly synthesized compounds displayed appreciable antiviral activity.
摘要
通过两种不同的环氧化物与三唑的甲基羧酸酯开环反应并进一步衍生化，制备了几种含有己糖醇部分的利巴韦林类似物。遗憾的是，新合成的化合物均未表现出明显的抗病毒活性。
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