单核苷SATE硫代磷酸葡萄糖苷作为一类新的前体核苷酸。
Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides.
作者信息
Jochum A, Schlienger N, Gosselin G, Imbach J L, Aubertin A M, Périgaud C
机构信息
Université Montpellier II, UMR 5625 CNRS, Montpellier, France.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):899-901. doi: 10.1081/NCN-120022681.
PMID:14565306
Abstract
The synthesis and the study of two phosphorothiolate derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and glucosyl residues associated to the phosphorus atom by a 2-oxyethyl link, are reported. These derivatives could be considered as prototypes of a new series of nucleotide prodrugs (pronucleotides).
摘要
报道了两种3'-叠氮基-2',3'-二脱氧胸苷（AZT）的硫代磷酸酯衍生物的合成及研究，其带有S-新戊酰基-2-硫代乙基（tBuSATE）基团以及通过2-氧乙基连接与磷原子相连的葡萄糖基残基。这些衍生物可被视为一系列新型核苷酸前药（前体核苷酸）的原型。
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