Luoni G, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J
Welsh School of Pharmacy, Cardiff University, Cardiff, UK.
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):931-3. doi: 10.1081/NCN-120022688.
We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3'-chloro and 5'-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity.
我们最近发现双环呋咱嘧啶是水痘带状疱疹病毒（VZV）的强效和选择性抑制剂。为了研究抗病毒活性的结构要求，我们成功合成了一些3'-氯和5'-氯衍生物。这些化合物已针对VZV和巨细胞病毒（CMV）进行了测试，但在体外未显示出显著活性。
