水痘带状疱疹病毒的双环核苷抑制剂：5'-氯和3'-氯衍生物。
Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives.
作者信息
Luoni G, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J
机构信息
Welsh School of Pharmacy, Cardiff University, Cardiff, UK.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):931-3. doi: 10.1081/NCN-120022688.
PMID:14565314
Abstract
We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3'-chloro and 5'-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity.
摘要
我们最近发现双环呋咱嘧啶是水痘带状疱疹病毒（VZV）的强效和选择性抑制剂。为了研究抗病毒活性的结构要求，我们成功合成了一些3'-氯和5'-氯衍生物。这些化合物已针对VZV和巨细胞病毒（CMV）进行了测试，但在体外未显示出显著活性。
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