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具有抗水痘带状疱疹病毒和人巨细胞病毒双重活性的新型双环呋喃嘧啶

Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.

作者信息

McGuigan Christopher, Brancale Andrea, Andrei Graciela, Snoeck Robert, De Clercq Erik, Balzarini Jan

机构信息

Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.

出版信息

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4511-3. doi: 10.1016/j.bmcl.2003.08.028.

DOI:10.1016/j.bmcl.2003.08.028
PMID:14643358
Abstract

Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 microM.

摘要

已经设计、制备并评估了几种新型双环呋喃嘧啶脱氧核苷作为抗水痘带状疱疹病毒（Varicella Zoster Virus，VZV）药物。这些化合物具有长醚侧链。在该家族的化合物中，目前的这些药物独特地显示出对VZV和人巨细胞病毒（human cytomegalovirus，HCMV）的双重活性。先导化合物在10 nM时抑制VZV，在5 μM时抑制HCMV。

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Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.具有抗水痘带状疱疹病毒和人巨细胞病毒双重活性的新型双环呋喃嘧啶
Bioorg Med Chem Lett. 2003 Dec 15;13(24):4511-3. doi: 10.1016/j.bmcl.2003.08.028.
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Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain.水痘-带状疱疹病毒的双环核苷抑制剂：对-烷基苯基侧链中支链的影响
Bioorg Med Chem Lett. 2005 Aug 15;15(16):3791-6. doi: 10.1016/j.bmcl.2005.05.071.

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