针对寡腺苷酸膦酸酯类似物的低聚反应。
Oligomerization aiming at phosphonate analogues of oligoadenylates.
作者信息
Pressová Martina, Liboska Radek, Budesínský Milos, Králíková Sárka, Kavenová Ivana, Rosenberg Ivan
机构信息
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1049-52. doi: 10.1081/NCN-120022733.
PMID:14565341
Abstract
This work deals with isopolar, phosphonate-based nucleotide analogues containing a bridging P-C bond instead of the ester P-O linkage. Specifically, starting from activated derivatives 1, 2, and 3, a simple process for preparation of mixtures of short oligomers and their analyses were elaborated.
摘要
这项工作涉及含桥连P-C键而非酯基P-O键的等极性膦酸酯基核苷酸类似物。具体而言，从活化衍生物1、2和3出发，阐述了一种制备短寡聚物混合物及其分析的简单方法。
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