Pressová Martina, Liboska Radek, Budesínský Milos, Králíková Sárka, Kavenová Ivana, Rosenberg Ivan
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1049-52. doi: 10.1081/NCN-120022733.
This work deals with isopolar, phosphonate-based nucleotide analogues containing a bridging P-C bond instead of the ester P-O linkage. Specifically, starting from activated derivatives 1, 2, and 3, a simple process for preparation of mixtures of short oligomers and their analyses were elaborated.
这项工作涉及含桥连P-C键而非酯基P-O键的等极性膦酸酯基核苷酸类似物。具体而言，从活化衍生物1、2和3出发，阐述了一种制备短寡聚物混合物及其分析的简单方法。
