基于等排体膦酸酯吡咯烷的二核苷单磷酸类似物。

Isosteric phosphonate pyrrolidine-based dinucleoside monophosphate analogues.

作者信息

Vanek Václav, Budesínský Milos, Kavenová Ivana, Rinnová Markéta, Rosenberg Ivan

机构信息

Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1065-7. doi: 10.1081/NCN-120022737.

DOI:10.1081/NCN-120022737

PMID:14565345

Abstract

A novel alpha- and beta-configured pyrrolidine nucleoside phosphonates in adenine series were synthesized from trans-4-hydroxy-L-proline as starting material. d(ApA) analogues were also prepared and studied with respect to their hybridization properties with polyU.

摘要

以反式-4-羟基-L-脯氨酸为起始原料，合成了腺嘌呤系列中一种新型的α-和β-构型吡咯烷核苷膦酸酯。还制备了d(ApA)类似物，并研究了它们与聚尿嘧啶的杂交特性。