核糖、木糖和阿拉伯糖构型的腺嘌呤基核苷膦酸酯：用于固相寡核苷酸组装的单体合成。
Ribo-, xylo-, and arabino-configured adenine-based nucleoside phosphonates: synthesis of monomers for solid-phase oligonucleotide assembly.
作者信息
Páv Ondrej, Budesínský Milos, Rosenberg Ivan
机构信息
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1053-6. doi: 10.1081/NCN-120022734.
PMID:14565342
Abstract
Adenine-based, regioisomeric nucleoside phosphonates with ribo, xylo and arabino configuration were synthesized in the protected form suitable for the phosphotriester-like, solid-phase synthesis of oligonucleotides. Phosphonate moiety was protected by 4-methoxy-1-oxido-2-picolyl group and the furanose hydroxyl by the dimethoxytrityl group.
摘要
合成了具有核糖、木糖和阿拉伯糖构型的腺嘌呤基区域异构体核苷膦酸酯，其为适合寡核苷酸类磷酸三酯固相合成的保护形式。膦酸酯部分由4-甲氧基-1-氧化-2-吡啶甲基基团保护，呋喃糖羟基由二甲氧基三苯甲基基团保护。
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