涉及2'-O,4'-C-亚甲基桥连核酸（2',4'-BNA）与2-吡啶酮碱基类似物的三链体形成：对C:G间断的高效且选择性识别。
Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 2-pyridone base analogue: efficient and selective recognition of C:G interruption.
作者信息
Torigoe Hidetaka, Hari Yoshiyuki, Obika Satoshi, Imanishi Takeshi
机构信息
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1097-9. doi: 10.1081/NCN-120022745.
For the effective recognition of C:G interruption in homopurine-homopyrimidine duplex DNA, we examined triplex-forming ability and sequence-selectivity of a triplex-forming oligonucleotide (TFO) involving of 2'-O,4'-C-methylene bridged nucleic acid with 2-pyridone base analogue. We found that the modified TFO formed stable triplex with high binding affinity and sequence-selectivity.
为了有效识别同型嘌呤-同型嘧啶双链DNA中的C:G中断，我们研究了一种包含2'-O,4'-C-亚甲基桥连核酸与2-吡啶酮碱基类似物的三链形成寡核苷酸（TFO）的三链形成能力和序列选择性。我们发现，修饰后的TFO形成了具有高结合亲和力和序列选择性的稳定三链体。
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