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涉及2'-O,4'-C-亚甲基桥连核酸（2',4'-BNA）与1-异喹诺酮碱基类似物的三链体形成：对C:G间断的高效且选择性识别。

Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption.

作者信息

Torigoe Hidetaka, Hari Yoshiyuki, Obika Satoshi, Imanishi Takeshi

机构信息

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1571-3. doi: 10.1081/NCN-120023036.

DOI:10.1081/NCN-120023036
PMID:14565468
Abstract

For the effective recognition of C x G interruption in homopurine-homopyrimidine duplex DNA, we examined triplex-forming ability and sequence-selectivity of a triplex-forming oligonucleotide (TFO) involving of 2'-O, 4'-C-methylene bridged nucleic acid with 1-isoquinolone base analogue. We found that the modified TFO formed stable triplex with high binding affinity and sequence-selectivity.

摘要

为了有效识别同型嘌呤-同型嘧啶双链DNA中的C×G中断，我们研究了一种包含2'-O，4'-C-亚甲基桥连核酸与1-异喹啉碱基类似物的三链形成寡核苷酸（TFO）的三链形成能力和序列选择性。我们发现修饰后的TFO形成了具有高结合亲和力和序列选择性的稳定三链体。

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Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption.涉及2'-O,4'-C-亚甲基桥连核酸（2',4'-BNA）与1-异喹诺酮碱基类似物的三链体形成：对C:G间断的高效且选择性识别。
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