α-羟基苄基膦酸酯修饰的寡核苷酸：合成、性质及通过单体构建块的新途径。
Alpha-hydroxybenzylphosphonate modified oligonucleotides: synthesis, properties, and a novel route via monomer building blocks.
作者信息
Hohlfeld Andreas, Meier Chris
机构信息
Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1123-5. doi: 10.1081/NCN-120022816.
PMID:14565360
Abstract
In general, alpha-hydroxybenzylphosphonate modified 2'-deoxyadenosine-thymidine dimer building blocks 1, 2 are utilized for the incorporation into alpha-hydroxybenzylphosphonate pro-oligonucleotides. For a universal application of our pro-oligonucleotide concept on biologically relevant oligonucleotides a route for the synthesis of modified monomer building blocks 3 was developed and is presented herein.
摘要
一般而言，α-羟基苄基膦酸酯修饰的2'-脱氧腺苷-胸腺嘧啶二聚体结构单元1、2用于掺入α-羟基苄基膦酸酯前体寡核苷酸中。为了使我们的前体寡核苷酸概念在与生物学相关的寡核苷酸上得到普遍应用，本文开发并展示了一种合成修饰单体结构单元3的路线。
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