• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

α-羟基苄基膦酸酯修饰的寡核苷酸：合成、性质及通过单体构建块的新途径。

Alpha-hydroxybenzylphosphonate modified oligonucleotides: synthesis, properties, and a novel route via monomer building blocks.

作者信息

Hohlfeld Andreas, Meier Chris

机构信息

Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1123-5. doi: 10.1081/NCN-120022816.

DOI:10.1081/NCN-120022816
PMID:14565360
Abstract

In general, alpha-hydroxybenzylphosphonate modified 2'-deoxyadenosine-thymidine dimer building blocks 1, 2 are utilized for the incorporation into alpha-hydroxybenzylphosphonate pro-oligonucleotides. For a universal application of our pro-oligonucleotide concept on biologically relevant oligonucleotides a route for the synthesis of modified monomer building blocks 3 was developed and is presented herein.

摘要

一般而言，α-羟基苄基膦酸酯修饰的2'-脱氧腺苷-胸腺嘧啶二聚体结构单元1、2用于掺入α-羟基苄基膦酸酯前体寡核苷酸中。为了使我们的前体寡核苷酸概念在与生物学相关的寡核苷酸上得到普遍应用，本文开发并展示了一种合成修饰单体结构单元3的路线。

相似文献

1
Alpha-hydroxybenzylphosphonate modified oligonucleotides: synthesis, properties, and a novel route via monomer building blocks.α-羟基苄基膦酸酯修饰的寡核苷酸：合成、性质及通过单体构建块的新途径。
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1123-5. doi: 10.1081/NCN-120022816.
2
Synthesis of high quality phosphorothioate oligonucleotides as antisense drugs. Use of I-linker in the elimination of 3'-terminal phosphorothioate monoesters.高质量硫代磷酸酯寡核苷酸作为反义药物的合成。I-连接体在消除3'-末端硫代磷酸单酯中的应用。
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1421-5. doi: 10.1081/NCN-120023000.
3
Oligonucleotide charge reversal: 2'-O-lysylaminohexyl modified oligonucleotides.寡核苷酸电荷反转：2'-O-赖氨酰氨基己基修饰的寡核苷酸。
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):939-42. doi: 10.1080/15257770701507978.
4
Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?具有等极性膦酸酯核苷酸间连接的寡核苷酸：反义化合物的新视角？
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):819-23. doi: 10.1081/NCN-100002437.
5
Synthesis and application of novel nucleoside phosphonates and phosphoramidites modified at the base moiety.碱基部分修饰的新型核苷膦酸酯和亚磷酰胺的合成与应用。
Acta Biochim Pol. 1996;43(1):45-52.
6
From ribonucleoside 5'-aldehydes to ribonucleoside 5'-C-phosphonates as building blocks for oligonucleotide synthesis.
Nucleic Acids Symp Ser (Oxf). 2008(52):591-2. doi: 10.1093/nass/nrn299.
7
Porphyrin substituted phosphoramidites: new building blocks for porphyrin-oligonucleotide syntheses.卟啉取代的亚磷酰胺：卟啉-寡核苷酸合成的新构建模块。
Bioorg Med Chem. 2005 Apr 1;13(7):2413-21. doi: 10.1016/j.bmc.2005.01.045.
8
2'-O-Lysylaminohexyl oligonucleotides: modifications for antisense and siRNA.2'-O-赖氨酰氨基己基寡核苷酸：用于反义核酸和小干扰RNA的修饰
ChemMedChem. 2008 Jan;3(1):102-10. doi: 10.1002/cmdc.200700169.
9
Antisense oligonucleotides: efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?反义寡核苷酸：使用4,5-二氰基咪唑高效合成2'-O-甲氧基乙基硫代磷酸酯寡核苷酸。这些寡核苷酸与使用1H-四氮唑作为偶联活化剂合成的寡核苷酸相比如何？
Bioorg Med Chem. 2006 Jul 15;14(14):5049-60. doi: 10.1016/j.bmc.2006.03.005. Epub 2006 Mar 23.
10
Improved synthesis of oligonucleotides with an allylic backbone. Oligonucleotides containing acyclic, achiral nucleoside analogues: N-1 or N-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]nucleobases.具有烯丙基主链的寡核苷酸的改进合成方法。含有无环、非手性核苷类似物的寡核苷酸：N-1或N-9-[3-羟基-2-(羟甲基)丙-1-烯基]核碱基。
Org Biomol Chem. 2006 Mar 21;4(6):1115-23. doi: 10.1039/b517504f. Epub 2006 Jan 25.