嘌呤 - 嘧啶间断位点处修饰寡核苷酸导向三链螺旋形成的合成与研究

Synthesis and studies of modified oligonucleotides-directed triple helix formation at the purine-pyrimidine interrupted site.

作者信息

Jazouli Mohamed, Guianvarc'h Dominique, Bougrin Khalid, Soufiaoui Mohamed, Vierling Pierre, Benhida Rachid

机构信息

Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Universitè des Sciences, Rabat, Morocco.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1277-80. doi: 10.1081/NCN-120022945.

DOI:10.1081/NCN-120022945

PMID:14565398

Abstract

Triple helix formation is still restricted to oligopurine-oligopyrimidine double stranded DNA target. Herein we focus on our progress achieved in nucleobase and oligonucleotide modifications area to address the chemical challenge to circumvent the recognition of a purine-pyrimidine base pair interruption in an oligopyrimidine-oligopurine DNA sequence.

摘要

三链螺旋的形成仍然局限于寡聚嘌呤-寡聚嘧啶双链DNA靶点。在此，我们重点介绍在核碱基和寡核苷酸修饰领域所取得的进展，以应对化学挑战，规避对寡聚嘧啶-寡聚嘌呤DNA序列中嘌呤-嘧啶碱基对中断的识别。