新型核碱基的掺入使得在含有嘌呤-嘧啶间断的靶序列处能够稳定地形成寡核苷酸导向的三链螺旋。
Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine.pyrimidine interruption.
作者信息
Guianvarc'h D, Benhida R, Fourrey J L, Maurisse R, Sun J S
机构信息
Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse 91198. Gif-sur-Yvette, France.
出版信息
Chem Commun (Camb). 2001 Sep 21(18):1814-5. doi: 10.1039/b103743a.
DOI:10.1039/b103743a
PMID:12240328
Abstract
Thermal denaturation experiments have established that an oligonucleotide incorporating the artificial nucleobase S, does form a stable triplex with a double stranded DNA which exhibits a pyrimidine interruption within the oligopurine sequence.
摘要
热变性实验已经证实，包含人工碱基S的寡核苷酸确实能与双链DNA形成稳定的三链体，该双链DNA在寡嘌呤序列内存在嘧啶间断。
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