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奈拉滨APIO类似物的设计、合成及体外评价

Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A.

作者信息

Moon Hyung Ryong, Kwon Sung Hee, Lee Jeong Ah, Yoo Byul Nae, Kim Hea Ok, Chun Moon Woo, Kim Hee-Doo, Kim Joong Hyup, Jeong Lak Shin

机构信息

College of Pharmacy, Ewha Womans University, Seoul, South Korea.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1475-7. doi: 10.1081/NCN-120023014.

DOI:10.1081/NCN-120023014
PMID:14565446
Abstract

A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed.

摘要

通过立体选择性醛醇-逆醛醇反应引入羟甲基，再经RCM反应合成碳环，从D-核糖高效合成了一种新型的奈拉滨A的阿皮奥类似物，并测定了其对SAH水解酶的抑制活性。

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引用本文的文献

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Synthesis of novel apio carbocyclic nucleoside analogues as selective a(3) adenosine receptor agonists.新型芹菜糖碳环核苷类似物作为选择性α(3) 腺苷受体激动剂的合成
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