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Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase.

作者信息

Moon Hyung Ryong, Lee Kang Man, Lee Joo Hyun, Lee Sang Kook, Park Seung Bin, Chun Moon Woo, Jeong Lak Shin

机构信息

College of Pharmacy, Pusan National University, Pusan 609-735, Korea.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):707-8. doi: 10.1081/NCN-200060286.

DOI:10.1081/NCN-200060286
PMID:16248019
Abstract

Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a hydrogen bonding donor is essential for inhibitory activity.

摘要

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