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Fluorescent 2-pyrimidinone nucleoside in parallel-stranded DNA.

作者信息

Kaluzhny D N, Mikhailov S N, Efimtseva E V, Borisova O F, Florentiev V L, Shchyolkina A K, Jovin T M

机构信息

Engelhardt Institute of Molecular Biology RASc, Moscow, Russia.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1499-503. doi: 10.1081/ncn-120023020.

Abstract

Stretches of parallel-stranded (ps) double-helical DNA can arise within antiparallel-stranded (aps) Watson-Crick DNA in looped structures or in the presence of sequence mismatches. Here we studied an effect of a pyrimidinone-G (PG) base pair on the stability and conformation of the ps DNA to explore whether P is useful as a structural probe.

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