肽核酸对双链DNA核酸外切酶降解的抑制作用及对核酸外切酶III的抑制作用
Suppression of exonucleolytic degradation of double-stranded DNA and inhibition of Exonuclease III by PNA.
作者信息
Slaitas A, Ander C, Földes-Papp Z, Rigler R, Yeheskiely E
机构信息
Division of Organic and Bioorganic Chemistry, MBB, Karolinska Institute, Stockholm, Sweden.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1603-5. doi: 10.1081/NCN-120023044.
PMID:14565476
Abstract
Degradation of double-stranded DNA by Exonuclease III in the presence of complementary anti-parallel PNA was studied. It was found for the first time that the PNA suppresses the degradation of dsDNA in a sequence-specific manner as well as inhibits the activity of Exonuclease III in a non-specific way.
摘要
研究了在存在互补反平行肽核酸（PNA）的情况下，核酸外切酶III对双链DNA的降解作用。首次发现，PNA以序列特异性方式抑制双链DNA的降解，并以非特异性方式抑制核酸外切酶III的活性。
Zotero 插件