Sheehan Nancy L, Kelly Deborah V, Tseng Alice L, van Heeswijk Rolf P G, Béïque Lizanne C, Hughes Christine A
Immunodeficiency Service, McGill University Health Centre (Montréal Chest Institute), Montréal, Québec, Canada.
Ann Pharmacother. 2003 Nov;37(11):1577-86. doi: 10.1345/aph.1D039.
Clinicians frequently consult HIV drug interaction Web sites of unknown quality.
To systematically review and identify HIV drug interaction Web sites of high quality and usefulness for healthcare professionals.
Relevant Web sites were identified through a structured search on commonly used search engines. An assessment tool containing 4 domains (content, reliability, access restrictions, ease of navigation) was developed. English and French Web sites were selected for review if they included HIV drug interaction information directed to healthcare professionals. Web sites were excluded if antiretroviral interaction data were not available or were out of date. Commercial online databases and sites that required payment were not included. Seventeen HIV pharmacists from across Canada participated in the review. The Web sites were ranked with total mean scores. Mean scores for each domain were then analyzed. Interrater agreement and ANOVA using the rater as a covariate were determined.
Nine Web sites met the criteria for review. Web sites from Toronto General Hospital (Canada), HIVinSite (beta version) (US), and the University of Liverpool (UK) ranked highest for total mean scores and for content. Other Web sites were found to be reliable, accessible, and easy to navigate; however, they did not consistently include unpublished data or data on herbal preparations, recreational drugs, or multiple interactions.
Three HIV interaction Web sites of high quality were identified that can be valuable tools for HIV and non-HIV health-care professionals. Regular reviews are necessary in order to keep pace with the growing body of HIV interaction data and the constant evolution of Web sites.
临床医生经常查阅质量不明的艾滋病病毒药物相互作用网站。
系统评价并确定对医疗保健专业人员而言高质量且有用的艾滋病病毒药物相互作用网站。
通过在常用搜索引擎上进行结构化搜索来识别相关网站。开发了一个包含4个领域（内容、可靠性、访问限制、导航便捷性）的评估工具。如果英文和法文网站包含针对医疗保健专业人员的艾滋病病毒药物相互作用信息，则选择其进行审查。如果抗逆转录病毒相互作用数据不可用或过时，则排除相关网站。不包括商业在线数据库和需要付费的网站。来自加拿大各地的17名艾滋病病毒药剂师参与了此次审查。根据总平均分对网站进行排名。然后分析每个领域的平均分。确定评分者间的一致性以及以评分者作为协变量的方差分析。
9个网站符合审查标准。多伦多综合医院（加拿大）、HIVinSite（测试版）（美国）和利物浦大学（英国）的网站在总平均分和内容方面排名最高。其他网站被认为可靠、可访问且易于导航；然而，它们并未始终包含未发表的数据或关于草药制剂、消遣性药物或多种相互作用的数据。
确定了3个高质量的艾滋病病毒相互作用网站，它们可以成为艾滋病病毒和非艾滋病病毒医疗保健专业人员的宝贵工具。为了跟上不断增长的艾滋病病毒相互作用数据以及网站的不断发展，需要定期进行审查。
