O'Brodovich H, Merritt T A
Hospital for Sick Children, Toronto, Ontario, Canada.
Am Rev Respir Dis. 1992 Dec;146(6):1613-4. doi: 10.1164/ajrccm/146.6.1613.
Fetal lung liquid secretion is essential for the normal growth of the lung in utero. Previous studies of fetal lung liquid secretion, mostly performed in lambs, have demonstrated that it has high Cl and very low HCO3- concentrations relative to plasma values. Because it is unknown whether primates have a similar electrolyte profile in their lung liquid, we sampled the lung liquid from rhesus monkeys (Macaca mulatta) at 127 to 128 days gestation (0.8 gestation). Although we found that lung liquid Cl concentration was higher than plasma values (p < 0.05), the HCO3- concentration was the same as in the plasma. This indicates that nonhuman primates, relative to lambs, have different cellular mechanisms for regulating fetal lung liquid HCO3- concentrations.
胎儿肺液分泌对于子宫内肺的正常生长至关重要。先前关于胎儿肺液分泌的研究大多在羔羊身上进行，结果表明，相对于血浆值，胎儿肺液中氯离子含量高而碳酸氢根离子浓度极低。由于尚不清楚灵长类动物的肺液中是否具有类似的电解质分布，我们在妊娠127至128天（妊娠0.8期）从恒河猴（猕猴）采集了肺液样本。尽管我们发现肺液中氯离子浓度高于血浆值（p < 0.05），但碳酸氢根离子浓度与血浆中的相同。这表明，相对于羔羊，非人灵长类动物调节胎儿肺液中碳酸氢根离子浓度的细胞机制有所不同。
