Weber Marc-André, Günther Matthias, Lichy Matthias P, Delorme Stefan, Bongers André, Thilmann Christoph, Essig Marco, Zuna Ivan, Schad Lothar R, Debus Jürgen, Schlemmer Heinz-Peter
Division Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany.
Invest Radiol. 2003 Nov;38(11):712-8. doi: 10.1097/01.rli.0000084890.57197.54.
To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI).
Sixty-two patients with brain metastases were examined on a 1.5 T-system up to 6 times during routine follow-up after stereotactic radiosurgery. Perfusion values in normal gray and white matter were measured using the ASL techniques ITS-FAIR in 38 patients, Q2TIPS in 62 patients, and the first-pass DSC echo-planar (EPI) MRI after bolus administration of gadopentetate dimeglumine in 42 patients. Precision of the ASL sequences was tested in follow-up examinations in 10 healthy volunteers.
Perfusion values in normal brain tissue obtained by all sequences correlated well by calculating Pearson's correlation coefficients (P < 0.0001) and remained unchanged after stereotactic radiosurgery as shown by analysis of variance (P > 0.05).
Both ASL and DSC EPI MRI yield highly comparable perfusion values in normal brain tissue.
使用动脉自旋标记（ASL）方法和首过动态磁敏感加权对比增强（DSC）磁共振成像（MRI）评估正常脑组织中的相对脑血流量（rCBF）。
62例脑转移瘤患者在立体定向放射治疗后的常规随访期间，在1.5T系统上接受了多达6次检查。在38例患者中使用ASL技术ITS-FAIR、62例患者中使用Q2TIPS测量正常灰质和白质中的灌注值，并在42例患者中在静脉注射钆喷酸葡胺后使用首过DSC回波平面（EPI）MRI进行测量。在10名健康志愿者的随访检查中测试了ASL序列的精度。
通过计算Pearson相关系数，所有序列获得的正常脑组织灌注值相关性良好（P < 0.0001），并且如方差分析所示，立体定向放射治疗后灌注值保持不变（P > 0.05）。
ASL和DSC EPI MRI在正常脑组织中产生的灌注值具有高度可比性。
