正常脑组织灌注成像中动脉自旋标记技术与动态磁敏感加权对比增强磁共振成像的比较
Comparison of arterial spin-labeling techniques and dynamic susceptibility-weighted contrast-enhanced MRI in perfusion imaging of normal brain tissue.
作者信息
Weber Marc-André, Günther Matthias, Lichy Matthias P, Delorme Stefan, Bongers André, Thilmann Christoph, Essig Marco, Zuna Ivan, Schad Lothar R, Debus Jürgen, Schlemmer Heinz-Peter
机构信息
Division Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany.
出版信息
Invest Radiol. 2003 Nov;38(11):712-8. doi: 10.1097/01.rli.0000084890.57197.54.
OBJECTIVES
To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI).
METHODS
Sixty-two patients with brain metastases were examined on a 1.5 T-system up to 6 times during routine follow-up after stereotactic radiosurgery. Perfusion values in normal gray and white matter were measured using the ASL techniques ITS-FAIR in 38 patients, Q2TIPS in 62 patients, and the first-pass DSC echo-planar (EPI) MRI after bolus administration of gadopentetate dimeglumine in 42 patients. Precision of the ASL sequences was tested in follow-up examinations in 10 healthy volunteers.
RESULTS
Perfusion values in normal brain tissue obtained by all sequences correlated well by calculating Pearson's correlation coefficients (P < 0.0001) and remained unchanged after stereotactic radiosurgery as shown by analysis of variance (P > 0.05).
CONCLUSION
Both ASL and DSC EPI MRI yield highly comparable perfusion values in normal brain tissue.
目的
使用动脉自旋标记（ASL）方法和首过动态磁敏感加权对比增强（DSC）磁共振成像（MRI）评估正常脑组织中的相对脑血流量（rCBF）。
方法
62例脑转移瘤患者在立体定向放射治疗后的常规随访期间，在1.5T系统上接受了多达6次检查。在38例患者中使用ASL技术ITS-FAIR、62例患者中使用Q2TIPS测量正常灰质和白质中的灌注值，并在42例患者中在静脉注射钆喷酸葡胺后使用首过DSC回波平面（EPI）MRI进行测量。在10名健康志愿者的随访检查中测试了ASL序列的精度。
结果
通过计算Pearson相关系数，所有序列获得的正常脑组织灌注值相关性良好（P < 0.0001），并且如方差分析所示，立体定向放射治疗后灌注值保持不变（P > 0.05）。
结论
ASL和DSC EPI MRI在正常脑组织中产生的灌注值具有高度可比性。
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