Neuroradiology, Amiens University Hospital, France.
Eur Neurol. 2010;64(1):21-6. doi: 10.1159/000311520. Epub 2010 Jun 19.
To prove the feasibility of arterial spin labeling (ASL) to explore brain tumors by comparing dynamic susceptibility contrast-enhanced MRI to ASL at 3T MR.
Twenty-seven patients were included presenting 9 gliomas, 10 metastases and 8 meningiomas. All were explored by a pseudo-continuous ASL and dynamic susceptibility contrast-enhanced T2* perfusion sequence. Two neuroradiologists analyzed the cerebral blood flow (CBF) maps to assess feasibility, examination quality and quantitative comparison. The Spearman nonparametric correlation test and the Bland-Altman graphic test were used to analyze our quantitative results.
92% of ASL CBF maps were informative. ASL detected all lesions as well as dynamic susceptibility contrast-enhanced MRI. Both sequences provide relative quantitative CBF values closely correlated.
On a 3T MR unit, ASL is a good alternative to dynamic susceptibility contrast-enhanced MRI when contrast medium is contraindicated or intravenous injection is not possible. Its results on relative CBF parameters are similar to contrast-injected perfusion.
通过比较 3T MR 的动态磁敏感对比增强 MRI 与动脉自旋标记（ASL），证明动脉自旋标记用于探索脑肿瘤的可行性。
27 名患者入组，包括 9 例胶质瘤、10 例转移瘤和 8 例脑膜瘤。所有患者均采用伪连续 ASL 和动态磁敏感对比增强 T2*灌注序列进行检查。两位神经放射科医生分析脑血流（CBF）图以评估可行性、检查质量和定量比较。采用 Spearman 非参数相关性检验和 Bland-Altman 图形检验分析我们的定量结果。
92%的 ASL CBF 图具有信息性。ASL 可检测到所有病变，与动态磁敏感对比增强 MRI 一样敏感。两种序列均提供密切相关的相对定量 CBF 值。
在 3T MR 设备上，当对比剂禁忌或无法进行静脉注射时，ASL 是动态磁敏感对比增强 MRI 的良好替代方法。其相对 CBF 参数结果与对比剂增强灌注相似。
