致畸剂量的6-氨基烟酰胺对兔胚胎DNA和RNA浓度的影响。
Effect of 6-aminonicotinamide in teratogenic doses on the DNA- and RNA-concentration in rabbit embryos.
作者信息
Scheil H G, Claussen U, Grote W
出版信息
Teratology. 1977 Dec;16(3):297-9. doi: 10.1002/tera.1420160308.
PMID:145662
Abstract
Pregnant rabbits were injected ip with 5 mg/kg 6-ANA at day 10, 11, 12 or 12.5 respectively of gestation. Embryos removed at day 13 of gestation had reduced DNA and RNA concentrations. The differences (DNA: 14 percent; RNA: 22.4 percent) were significant in the group treated on the twelfth day. Some possible mechanisms are discussed.
摘要
在妊娠第10天、11天、12天或12.5天，分别给怀孕的兔子腹腔注射5毫克/千克的6-氨基烟酰胺（6-ANA）。在妊娠第13天取出的胚胎，其DNA和RNA浓度降低。在第12天接受治疗的组中，差异（DNA：14%；RNA：22.4%）具有显著性。文中讨论了一些可能的机制。
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