Stein Murray B
Department of Psychiatry, University of California-San Diego, La Jolla, CA 92037, USA.
Psychopharmacol Bull. 2003 Spring;37 Suppl 1:97-107.
Social anxiety disorder frequently begins in early life and is associated with the subsequent development of comorbid conditions such as depressive and substance use disorders. Social anxiety disorder, particularly the generalized subtype, is characterized by marked impairment in numerous functional domains, including education and social relations. Paroxetine, the first medication to receive an indication in the United States for the treatment of social anxiety disorder, has been shown to be effective in 50% to 60% of patients. The mechanism of action of paroxetine in the treatment of social anxiety disorder is at present unclear. A possible role for early treatment to prevent complications of social anxiety disorder should be explored.
社交焦虑障碍常始于早年，并与后续共病情况的发展相关，如抑郁和物质使用障碍。社交焦虑障碍，尤其是广泛性亚型，其特征是在包括教育和社会关系在内的众多功能领域存在明显损害。帕罗西汀是美国首个获批用于治疗社交焦虑障碍的药物，已证明对50%至60%的患者有效。目前尚不清楚帕罗西汀治疗社交焦虑障碍的作用机制。应探索早期治疗预防社交焦虑障碍并发症的可能作用。
