Wagner Karen Dineen
Department of Psychiatry, University of Texas Medical Branch, TX 77555-0188, USA.
Psychopharmacol Bull. 2003 Spring;37 Suppl 1:167-75.
This article provides an overview of the use of paroxetine in the treatment of mood and anxiety disorders in children and adolescents. Although not currently approved for use in patients younger than 18 years of age, the efficacy and safety of paroxetine have been studied in several pediatric mood and anxiety disorders. The epidemiology, diagnosis, and course of major depression, obsessive-compulsive disorder, social anxiety disorder, and panic disorder are discussed briefly. Current available data on the safety and efficacy of paroxetine based on double-blind, placebo-controlled trials and open-label studies for the treatment of mood and anxiety disorders in children and adolescents are reviewed. Clinical guidelines for the use of paroxetine in children and adolescents and recommendations regarding future directions of study are discussed.
本文概述了帕罗西汀在儿童和青少年情绪及焦虑障碍治疗中的应用。尽管目前尚未批准用于18岁以下患者，但已对帕罗西汀在几种儿童情绪和焦虑障碍中的疗效和安全性进行了研究。文中简要讨论了重度抑郁症、强迫症、社交焦虑症和恐慌症的流行病学、诊断及病程。回顾了基于双盲、安慰剂对照试验和开放标签研究得出的关于帕罗西汀治疗儿童和青少年情绪及焦虑障碍的安全性和疗效的现有数据。还讨论了儿童和青少年使用帕罗西汀的临床指南以及关于未来研究方向的建议。
