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危重症内科和外科患者多器官功能障碍（MOD）评分的验证

Validation of the multiple organ dysfunction (MOD) score in critically ill medical and surgical patients.

作者信息

Buckley Thomas A, Gomersall Charles D, Ramsay Sarah J

机构信息

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.

出版信息

Intensive Care Med. 2003 Dec;29(12):2216-2222. doi: 10.1007/s00134-003-2037-z. Epub 2003 Oct 18.

DOI:10.1007/s00134-003-2037-z
PMID:14566459
Abstract

OBJECTIVE

To validate the Multiple Organ Dysfunction (MOD) score externally.

DESIGN

Prospective observational cohort study.

SETTING

Mixed medical/surgical ICU in a tertiary referral university hospital.

PATIENTS AND PARTICIPANTS

Thousand eight hundred and nine patients admitted to ICU for more than 24 h over a 3-year period.

INTERVENTIONS

None.

MEASUREMENTS AND RESULTS

The MOD score was calculated daily for all patients. The criterion validity of the individual organ scores, the maximal MOD score and the change in MOD score were assessed by examining the relationship between increasing scores and ICU mortality. Increased maximal MOD scores and each of the six individual organ scores, and change in MOD scores were associated with increased mortality.

CONCLUSIONS

Maximal and individual organ scores have criterion validity when tested in a different ICU from that in which the scores were derived, indicating that the scoring systems are reproducible. The association of change in MOD score with mortality indicates that the score is responsive. These data, combined with previous data establishing concept and content validity, indicate that the MOD score is a valid measure of multi-organ dysfunction.

摘要

目的

对外验证多器官功能障碍（MOD）评分。

设计

前瞻性观察队列研究。

地点

一所三级转诊大学医院的内科/外科混合重症监护病房。

患者和参与者

在3年期间入住重症监护病房超过24小时的1809名患者。

干预措施

无。

测量和结果

每天为所有患者计算MOD评分。通过检查评分增加与重症监护病房死亡率之间的关系，评估单个器官评分、最大MOD评分和MOD评分变化的标准效度。最大MOD评分增加、六个单个器官评分中的每一个增加以及MOD评分变化均与死亡率增加相关。

结论

当在不同于得出评分的重症监护病房中进行测试时，最大和单个器官评分具有标准效度，表明评分系统具有可重复性。MOD评分变化与死亡率的关联表明该评分具有反应性。这些数据与先前确立概念和内容效度的数据相结合，表明MOD评分是多器官功能障碍的有效度量。

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