Stang Andreas, Ahrens Wolfgang, Anastassiou Gerasimos, Jöckel Karl-Heinz
Institute for Medical Informatics, Biometry & Epidemiology, Medical Faculty, University of Essen, Germany.
Ophthalmic Epidemiol. 2003 Dec;10(5):293-302. doi: 10.1076/opep.10.5.293.17319.
To investigate potential risk factors of uveal melanoma, including phenotypical characteristics, eye burns, social class, smoking and alcohol consumption.
A hospital-based and population-based case-control study of uveal melanoma was carried out from 1995 through 1998 and the results pooled. A total of 118 patients (59 men and 59 women) with uveal melanoma and 475 controls matching on sex, age and study regions were interviewed. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95% CI).
There was an elevated risk for blue or grey iris color (OR = 3.0, 95% CI 1.5-6.0). Red or blond hair color at age 20 was slightly associated with an increased risk for uveal melanoma (OR = 1.5, 95% CI 0.9-2.4). There was no elevated risk for a history of eye burns (OR = 1.1, 95% CI 0.5-2.4).
Among the potential risk factors studied, only the phenotypical characteristics showed an association with the risk of uveal melanoma.
研究葡萄膜黑色素瘤的潜在风险因素，包括表型特征、眼部烧伤、社会阶层、吸烟和饮酒情况。
1995年至1998年开展了一项基于医院和人群的葡萄膜黑色素瘤病例对照研究，并汇总结果。共对118例葡萄膜黑色素瘤患者（59例男性和59例女性）以及475例在性别、年龄和研究地区相匹配的对照进行了访谈。采用条件逻辑回归计算比值比（OR）和95%置信区间（95%CI）。
蓝色或灰色虹膜颜色的风险升高（OR = 3.0，95%CI 1.5 - 6.0）。20岁时红色或金色头发颜色与葡萄膜黑色素瘤风险略有增加相关（OR = 1.5，95%CI 0.9 - 2.4）。眼部烧伤史的风险未升高（OR = 1.1，95%CI 0.5 - 2.4）。
在所研究的潜在风险因素中，只有表型特征显示与葡萄膜黑色素瘤风险相关。
