一项针对九个欧洲国家的病例对照研究得出的葡萄膜黑色素瘤职业风险。

Occupational risks for uveal melanoma results from a case-control study in nine European countries.

作者信息

Lutz Jean-Michel, Cree Ian, Sabroe Svend, Kvist Tine Kajsa, Clausen Lene Bjørk, Afonso Noemia, Ahrens Wolfgang, Ballard Terri J, Bell Janine, Cyr Diane, Eriksson Mikael, Févotte Joëlle, Guénel Pascal, Hardell Lennart, Jöckel Karl-Heinz, Miranda Ana, Merletti Franco, Morales-Suarez-Varela Maria M, Stengrevics Aivars, Lynge Elsebeth

机构信息

Registre Genevois des Tumeurs, Geneva, Switzerland.

出版信息

Cancer Causes Control. 2005 May;16(4):437-47. doi: 10.1007/s10552-004-5029-6.

DOI:10.1007/s10552-004-5029-6

PMID:15953986

Abstract

OBJECTIVE

Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors.

METHODS

A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%.

RESULTS

Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma.

CONCLUSION

Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.

摘要

目的

葡萄膜黑色素瘤是一种罕见疾病，预后较差，病因大多不明。我们研究了潜在的职业风险因素。

方法

1995年至1997年期间，在9个欧洲国家开展了一项基于人群的病例对照研究，以人群和结肠癌患者作为对照，并进行个人访谈。使用工作暴露矩阵评估职业性阳光照射和人工紫外线辐射暴露情况。经病理检查，共有320例葡萄膜黑色素瘤病例符合条件，其中292例接受了访谈，参与率为91%。在3357名人群对照中，2062名接受了访谈，参与率为61%；在1272名癌症对照中，1094名接受了访谈，参与率为86%。

结果

以人群作为对照时，职业性阳光照射与风险增加无关（相对危险度RR = 1.24，95%可信区间CI = 0.88 - 1.74），而以结肠癌患者作为对照时发现的风险过高归因于混杂因素。焊工的风险过高仅限于法国的数据部分。厨师的RR = 2.40；清洁工的RR = 2.15；洗衣工的RR = 3.14，患葡萄膜黑色素瘤的风险增加。