在增溶剂存在的情况下，大鼠肠道对氯碘羟喹的吸收增加。

Increased absorption of iodochlorhydroxyquin by rat intestine in the presence of solubilizing agents.

作者信息

Kasai M, Kanamitsu M, Katada T, Tokumitsu Y, Itaya K, Ui M

出版信息

Toxicology. 1977 Dec;8(3):327-32. doi: 10.1016/0300-483x(77)90080-4.

Abstract

The intestinal absorption of iodochlorhydroxyquin (clioquinol) by the rat was studied by determining the radioactivity in the bile, blood and several organs 90 min after direct application of 125I-labeled clioquinol into the duodenum. The addition of solubilizing agents such as carboxymethyl-cellulose and lauryl sulfate to clioquinol preparation markedly enhanced the intestinal absorption of the drug in either the presence of absence of bile secretion which, by itself, increased the drug absorption. Possible significance of the enhanced absorption of clioquinol by solubilizing agents in the etiology of subacute myelo-optic neuropathy (SMON) in Japan is discussed.

摘要

通过将125I标记的氯碘喹啉直接注入十二指肠90分钟后，测定胆汁、血液和多个器官中的放射性，研究了大鼠对氯碘喹啉（clioquinol）的肠道吸收情况。在氯碘喹啉制剂中添加增溶剂如羧甲基纤维素和月桂基硫酸盐，无论有无胆汁分泌，均显著增强了该药的肠道吸收，而胆汁分泌本身也会增加药物吸收。文中讨论了增溶剂增强氯碘喹啉吸收在日本亚急性脊髓视神经病（SMON）病因学中的可能意义。