Mörike K, Gleiter C H
Abteilung Klinische Pharmakologie, Institut für Pharmakologie und Toxikologie, Universitätsklinikum Tübingen.
Internist (Berl). 2003 Jun;44(6):748-52. doi: 10.1007/s00108-003-0969-6.
Herbal drugs are popular. Coming from nature, many people are still reluctant to link them with the risk of adverse effects. Many of these products do not require a prescription. Thus, their use and any potential risks may easily escape the physician's attention. Interactions, causing either adverse effects or treatment failures, with synthetic drugs have attracted increasing interest and recent case reports (e.g. about patients suffering from transplant rejection upon using of St John's wort with subsequently insufficient cyclosporine levels) have triggered some systematic research. As of yet, however, a substantial part of knowledge is based on case reports only. In this situation, the assessment of potential risks arising from herb drug interactions is difficult. More research is needed. This review is a brief account of interactions involving garlic, ginkgo, ginseng, echinacea, and St John's wort.
草药很受欢迎。由于来自天然，许多人仍然不愿将它们与不良反应风险联系起来。这些产品中的许多都不需要处方。因此，它们的使用以及任何潜在风险可能很容易被医生忽视。与合成药物发生相互作用，导致不良反应或治疗失败，已引起越来越多的关注，最近的病例报告（例如，关于使用圣约翰草后出现移植排斥反应且随后环孢素水平不足的患者）引发了一些系统性研究。然而，截至目前，相当一部分知识仅基于病例报告。在这种情况下，评估草药相互作用产生的潜在风险很困难。需要更多的研究。本综述简要介绍了涉及大蒜、银杏、人参、紫锥菊和圣约翰草的相互作用。
